The 10 Best Supplements for Weight Loss and Muscle Gain

When it comes to crushing it at the gym, you want to do yourself as many favors as you can. This involves the right combination of physical activity, sleep, and proper nutrition.

Another great thing to throw into this mix are the best supplements for weight loss and muscle gain; because even though you want whole foods that are packed with the nutrients you need, there are some combinations out there that give you what foods can’t.

5 Best Supplements for Weight Loss: Editor Recommended

10 Best Supplements for Weight Loss

1. MuscleTech NitroTech Protein Powder Plus Muscle Builder

MuscleTech NitroTech Protein Powder Plus Muscle Builder
  • WHEY PROTEIN POWDER – MuscleTech Nitro-Tech is the most powerful protein formula ever developed. It is a scientifically engineered whey plus isolate lean muscle builder formula designed for more muscle, more strength and better performance
  • MUSCLE BUILDER for MEN & WOMEN – MuscleTech Nitro-Tech has 5g of glutamine & precursor, 6.8g of BCAA and a clinically studied 3g dose of HPLC-tested creatine monohydrate to help build lean muscle, increase strength and enhance performance for men &...
  • PROTEIN POWDER for MUSCLE GAIN – In a 6-week, double-blind study involving the core ingredients of Nitro-Tech, subjects gained 70% more lean muscle than those using regular whey (8.8 vs 5.1 lbs) and increased their bench press more (34 vs 14 lbs)....
  • CREATINE MONOHYDRATE – Start re-imagining the limits of size and strength with pure, HPLC-tested creatine. Scientific studies have shown that it helps replenish ATP stores in the body for enhanced performance, more muscle and an increase in strength
  • ABSORBS FAST and DIGESTS EASILY – Whey peptides are an ultra-pure, rapidly absorbed and quickly digested whey protein powder that allows you to recover faster, build more lean muscle and get better results from your training sessions
  • DAILY WORKOUT SUPPLEMENTS – Mix 1 scoop with 6 oz of water or skim milk between meals & after exercise


This product is scientifically proven to build 70 percent more muscle than regular whey protein. This alone is reason enough to invest in it. It also contains compounds proven to aid recovery along with a micronization process that reduces fat and lactose naturally.


Ingredients contained within include glutamine, BCAA aminos, and a hefty dose of creatine along with the whey.


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2. NatureWise CLA 1250

NatureWise CLA 1250
  • Promote Muscle Growth: CLA supplements may support metabolic activity and lean muscle gain.* CLA may encourage the body’s production of energy for sustained physical activity.*
  • Encourage Exercise Benefits: Conjugated Linoleic Acid, or CLA, may encourage greater benefits from exercise by influencing the activity of certain enzymes that play a role in the metabolism of fatty acids.* CLA may also contribute to the production of...
  • Premium Quality: NatureWise CLA comes from pure, premium-quality, non-GMO safflower oil obtained from certified sources and standardized to a high potency of 80%. Each 1250 mg softgel contains 1000 mg of CLA.
  • Natural & Non-Stimulating: Unlike many popular bodybuilding supplements, our CLA supplement is made with clean, simple, natural ingredients that are non-stimulating, non-addictive, and safe for ongoing use.
  • 2-Month Supply: Includes 180 softgel capsules. Standard Serving: Adults take 1 softgel three times daily with meals. Maximum Serving: Adults take 3 softgels three times daily with meals.


This supplement helps form a high metabolism that will contribute to weight loss due to the conjugated linoleic acid that acts as a thermogenic fat burner. This means your body is more likely to burn fat during your workouts than other sources of energy.


The only strong ingredient contained within is conjugated linoleic acid extracted from safflower oil.

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3. Bulksupplements Creatine Monohydrate Powder

Bulksupplements Creatine Monohydrate Powder
  • 💪 Increases Muscle Mass - Creatine, or Creatine Monohydrate is one of the most widely-used bodybuilding supplements. If you're trying to pack on lean muscle mass, supplementing with creatine monohydrate powder, or creatine nutritional supplements, can...
  • 🏃 Boosts Exercise Performance - Creatine monohydrate powder, or micronized creatine monohydrate, helps boost performance in short duration high intensity activities such as weightlifting by increasing the amount of ATP available to your body's...
  • 🧠 Supports Brain Health - Our bodies naturally produce creatine, or micronized creatine monohydrate, but many people don't consume enough in their diet (especially vegetarians). Supplementing with creatine powder supplies energy to all your cells,...
  • ✔️ Workout with Creatine - Unlike some other supplements, Our creatine powder is micronized and is an effective form of creatine supplements which makes it more easily absorbed by the body. Simply add it to your favorite beverage or any shake. It's...
  • ⭐ High Quality - All products by BulkSupplements are manufactured according to cGMP Standards to ensure the highest quality for manufacturing, packaging, labeling, and holding operations. We’ve made a significant investment in our in-house lab so we...


If it’s creatine you want, this is the best place to find it. Creatine stimulates muscle recovery and also allows you to work out harder. It also dissolves easily in water, making this a great addition to your pre or post workout shake. Creatine itself is one of the most important of our best supplements for weight loss and muscle gain.


The only ingredient found here is creatine.

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4. NOW® Sports L-Glutamine Powder


L-Glutamine is essential for the rapid growth of digestive cells and cells in the immune system. It also helps the body transport nitrogen. These reasons plus a healthy nitrogen balance make it a great companion for your workouts.


The only ingredient contained here is free-form L-Glutamine.

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5. LABRADA Nutrition – Lean Body High Protein Meal Replacement Shake

LABRADA Nutrition – Lean Body High Protein Meal Replacement Shake
  • LEAN BODY contains 35g of fast-release and slow-release proteins, to give you a sustained flow of vital amino acids for faster muscle growth and increases in strength.
  • AWARD WINNING TASTE - Lean Body is a 5-time winner of the American Culinary Institute’s Gold Medal Taste Award.
  • ALL-IN-ONE MRP - Forget other supplement pills and powders — you get it all in Lean Body : concentrated muscle-building, fat burning nutrition in one delicious, easy-to-make shake.
  • SCIENTIFICALLY TESTED - In an eight-week, doctor-supervised study, participants using LEAN BODY in conjunction with their exercise regimen gained, on average, 6.5 lbs. of lean muscle mass, and lost 14.4 lbs. of body fat.
  • NO JUNK - LEAN BODY is free of maltodextrin, artificial colors, aspartame, preservatives and trans fats


Meal replacement shakes are great for when you don’t want to eat a full meal during breakfast, lunch, or dinner. Here you’ve got a combination of fast and slow release proteins. It also boasts scoring a great taste award from the American Culinary Institute. This causes it to go above and beyond on our list of the best supplements for weight loss and muscle gain.


Primary ingredients include whey protein concentrate, non-dairy creamer, mono and diglycerides, dipotassium phosphate, tricalcium phosphate, soy lecithin, milk protein isolate, and dutch cocoa.

6. MuscleTech Platinum Creatine Monohydrate Powder

MuscleTech Platinum Creatine Monohydrate Powder
  • CREATINE MONOHYDRATE POWDER – MuscleTech Platinum Creatine delivers 5g of 100% pure, HPLC-tested, micronized creatine monohydrate to increase lean muscle, improve strength and muscle endurance
  • MUSCLE BUILDER for MEN & WOMEN – Platinum Creatine delivers creatine directly to your muscles, driving performance. Test subjects increased their bench press strength by an amazing 18.6% in just 10 days
  • MUSCLE RECOVERY – Creatine helps to replenish ATP levels in hard-working muscles. This allows you to train harder, for longer
  • SINGLE INGREDIENT – No fillers. No sugar. Unflavored. Fits with a ketogenic diet
  • DAILY WORKOUT SUPPLEMENTS – For the first 3 days (loading phase): Mix 1 scoop with 8 oz of water (or other drink) and consume 4 times daily. After day 3 (maintenance phase): Mix 1 scoop with 8 oz of water (or other drink) and consume 1 to 2 times daily


This brand of creatine is micronized and highly concentrated, giving you a lot of extra energy and recovery assistance. Make sure you add this or another form of creatine to your supplement game.


The only ingredient listed here is micronized creatine monohydrate.

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7. Omega 3 Fish Oil 2250mg

Omega 3 Fish Oil 2250mg
  • High dose of 4,080mg Omega 3 fish oil; higher EPA and DHA levels than other brands with a total of 2,250mg Omega 3 fatty acid content
  • Ultra pure and refined; purified with molecular distillation at minimal temperatures to remove all heavy metals, mercury and PCB's
  • 100% wild ocean catch; from fresh, deep sea sourced, omega-rich fish; special extraction method for the highest volume of EPA and DHA; sustainable and traceable; triple certified by Marin Trust, Friend of the Seas and Dolphin Safe
  • Burpless, natural lemon flavor; odorless & easy to swallow without fishy burps; our fish oil concentrates are fresher than other brands; shown by extremely low oxidation (Totox) values less than 5 meq/kg which is the highest quality in the market
  • Reliable; made in a GMP certified facility in America and heavy metal tested for purity; we use a superior patented oil extraction method that results in extremely low levels of contaminants, oxidation and pollutants


Fish oil powers your brain tissue and also lubricates your muscles, which allow them to go for longer. It can also help fight inflammation of the joints and muscles as well as contribute to optimal heart health.


The only ingredient contained here is fish oil.

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  • Packaging May Vary - New look, with the same trusted quality
  • GOLD STANDARD 100% WHEY BLEND – 24g blended protein consisting of whey protein isolate, whey protein concentrate, and whey peptides to support lean muscle mass – they don't call it the GOLD STANDARD of quality for nothing
  • OVER 5G OF BCAAS – help build lean and strong muscles with naturally occurring BCAAs
  • 3-4G CARBS, 1-3G SUGAR, AND 1-1.5G FAT, GLUTEN FREE, No Sucralose in Double Rich Chocolate Flavor
  • INSTANTIZED – improves mixability to prevent lumps and clumps
  • BANNED SUBSTANCE TESTED – highest quality control measures so you feel comfortable and safe consuming the product
  • 8 SIZES TO CHOOSE FROM – 1, 2, 5, and 10-pound options available


There’s a reason they call it the gold standard. This form of whey protein powder has been around for a long time and has been trusted again and again. The BCAA amino acids contained within can kick start muscle recovery both before and after workouts.

Make sure you remember to take it with you and give your system a fighting chance when it comes to having the protein it needs. This product is a classic when it comes to the best supplements for weight loss and muscle gain.


The only ingredient contained here is whey protein.

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9. OPTIMUM NUTRITION L-Glutamine Muscle Recovery Capsules

OPTIMUM NUTRITION L-Glutamine Muscle Recovery Capsules
  • 1000 milligram of pure l glutamine per 2 capsules
  • Most abundant amino acid in the body
  • Plays an important role in muscle protein development
  • During prolonged periods of intense exercise, glutamine levels may be depleted
  • Package may vary (120 count or 240 count)
  • During the summer months products may arrive warm, but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided


Want all the benefits of glutamine without having to take it in a powder? Well here’s your answer. These muscle recovery capsules come with 240 per container, giving you all of the glutamine you’ll need for a while. Unless you go hard more often, that is. The best supplements for weight loss and muscle gain give the best results when you work out often.


The only ingredients contained here are L-Glutamine, gelatin, and magnesium stearate.

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10. Solimo Adult One Daily Multivitamin Multimineral

Solimo Adult One Daily Multivitamin Multimineral
  • 365 tablets, a one year supply (taken daily at listed serving size)
  • A blend of 30 vitamins and minerals per serving (1 tablet)
  • No artificial flavors, no gluten, no lactose
  • Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385
  • An Amazon brand
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.


A good multivitamin is essential as an individual moves through the modern lifestyle. Multivitamins basically rebalance the body’s nutrition needs wherever one’s diet has fallen short. When taken with other foods, the body absorbs the nutrients contained within and those compounds are then readily available.

Of course it’s ideal to get a great deal of your vitamins and minerals from whole food sources, but this isn’t always possible. Solimo Adult One Daily Multivitamin Multimineral contains a blend of 30 vitamins and minerals, providing a capstone on the arc of your nutritional make up.

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There are several ingredients to include here. More than any other suppliment we’ve mentioned. They are: Calcium Carbonate, Potassium Chloride, Dicalcium Phosphate, Magnesium Oxide, Microcrystalline Cellulose, Maltodextrin, Ascorbic Acid, Ferrous Fumarate.

Contains 2% or less of beta-carotene, BHT, biotin, carboxymethylcellulose sodium, cholecalciferol, chromium picolinate, cupric sulfate, cyanocobalamin, D-calcium pantothenate, dl-alpha tocopherol, dl-alpha tocopheryl acetate, DL-tartaric acid, FD&C blue no. 2 lake, FD&C red no. 40 lake, FD&C yellow no. 6 lake, folic acid, gelatin, and glucose

Also contained: gum arabic, hydroxypropyl methylcellulose, magnesium stearate, manganese sulfate, medium chain triglycerides, nickel sulfate, nicotinamide, phytonadione, polydextrose, polyethylene glycol, polyvinyl alcohol, potassium iodide, pyridoxine hydrochloride, retinyl acetate, riboflavin, silicon dioxide, sodium ascorbate, sodium benzoate, sodium metavanadate, sodium molybdate, sodium selenite, sorbic acid, stannous chloride, starch, sucrose, sunflower oil, talc, thiamine mononitrate, titanium dioxide, tocopherol, tricalcium phosphate, zinc oxide. May contain carnauba wax, povidone, sodium selenate, triacetin.

Frequently Ask Question About Supplements for Weight Loss

1. What Makes Up the Best Supplements for Weight Loss and Muscle Gain?

You want supplements that simultaneously stimulate the metabolism while providing some common missing links in the amino acid chains that make up the proteins that build muscle. There are also certain vitamins and minerals that people chronically lack. Supplements do a good job at providing this too.

On top of this, there are certain compounds that boost testosterone, the body’s natural performance enhancer. Looking for supplements that include these herbs and substances can help here big time.

2. How Many Supplements Should I Take?

You’ve got to remember that supplements are formed in very specific combinations. These combinations give the body exactly what it needs to do certain things. It may be tempting to try to ‘buy the store’ when it comes to maxing out your nutritional stats. But this would be a grave error.

Should you go this route you’ll be reminded in not-so-subtle ways that everything you put in your body must be processed by your body. If you give it too much at once, it does not go well. Instead, try to target a system of the body for a short period of time before moving onto the next. This way you can hack nutrition like you hack pumping.

3. What Will Help You Absorb Supplements?

No matter what supplements you take, it won’t make much of a difference if the nutrients contained within are not absorbed by your body. So what can you do to make sure your supplements are bringing the full effect? First of all, make sure to drink lots of water between meals.

Your body will thank you in more ways than one. Also, take a break from coffee and alcohol, as these substances encourage you to lose optimal hydration fast. Also, consider taking probiotics, since they help break down nutrients quickly. Finally make sure to relax and eat a variety of different foods. Stress causes malabsorption, as can eating too much of one thing.

4. What Happens if I Accidentally Don’t Work Out?

So you’re taking your supplements. Then what? You skipped the gym a few times this week and took some mornings off from running? Now the best supplements for weight loss and muscle gain may be having other effects. The makers of these supplements assume that you’re working out hard.

Don’t let them down or you’ll be letting yourself down. Your body might go through emotional stress without an outlet for all of the energy that’s being stimulated. In addition, the compounds that cause you to build muscle may cause you to actually store fat if you don’t work out.

5. What’s the Best Timing to Take Supplements?

This of course depends on what kind of supplement it is. Pre-workout supplements are best taken about a half hour to 45 min before you start your exertion. Next, make sure that you’ve got plenty of time to sleep after a particularly strenuous work out day.

For recovery supplements and post-work out nutrition, be sure to get that goodness into your system as close to the end of your workout as possible, or no longer than 30 minutes afterward. This maximizes the potential of protein synthesis, or the process of muscle growth.

How We Reviewed

We made sure to only list supplements that make the grade in a variety of arenas. Are they scientifically proven to give you results? Are they easy to digest and not give you any side effects? Can you take them for an extended period of time? Do the ones that come in the form of powder taste good? The more a supplement soared in these areas, the more likely they were to make our list. You’ll find those that did below.

Overall Price Range

When pricing out supplements, it’s difficult to measure their worth based on the ingredients alone. They’re involved in a lifestyle that you’re already committed to. That said, you can expect to pay between 15 and 100 dollars for the supplements we’ve listed.

Different supplements do different things, and some have higher costs to make than others. But taking the best supplements for weight loss and muscle gain are going to be worth it in the long run.

What We Reviewed

  • MuscleTech NitroTech Protein Powder Plus Muscle Builder
  • NatureWise CLA 1250
  • Bulksupplements Creatine Monohydrate Powder
  • NOW® Sports L-Glutamine Powder
  • LABRADA Nutrition – Lean Body High Protein Meal Replacement Shake, Whey Protein Powder for Weight Loss and Muscle Growth
  • MuscleTech Platinum Creatine Monohydrate Powder
  • Omega 3 Fish Oil 2250mg
  • OPTIMUM NUTRITION L-Glutamine Muscle Recovery Capsules
  • Solimo Adult One Daily Multivitamin Multimineral

Final Verdict

It took a lot of thought because choosing the winning supplement also means prioritizing what kind of supplement is most important. So make sure that in addition to looking at the winner we chose, you also decide for yourself what kind of supplement you require based on your body’s needs.

For us though, the most impressive supplement we looked at was LABRADA Nutrition – Lean Body High Protein Meal Replacement Shake, Whey Protein Powder for Weight Loss and Muscle Growth. The reason we chose this was because it was the most all-inclusive of all of the supplements.

It was also the best tasting according to the American Culinary Institute. And taste matters, especially if you’re going to be ingesting these supplements on a regular basis. Again, make sure that you don’t lean on these supplements too heavily.

Even in the case of our winner, you shouldn’t be replacing more than one meal a day. Like with anything else in life, it’s all about balance: even with the best supplements for weight loss and muscle gain.



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